Abstract. The article provides an analysis of enterprises located in the Khmelnytskyi region, their characteristics are described, and an analysis of their impact on water ecosystems is conducted. Their sanitary protection zone and hazard class have been determined. It has been determined that the largest water user is the municipal water supply and sanitation enterprise in the city of Krasyliv, the communal enterprise “Miskvodokanal”, the communal enterprise “Izyaslavvodokanal”, Theofipol Housing and Utilities Management Production Department, and Aslan-Textile LLC. These companies are the largest water consumers in terms of volume and also discharge significant amounts of wastewater into surface waters.

According to the monitoring studies presented in the article, concentrations of pollutants in the control sections of water bodies in Khmelnytskyi region were within the permissible limits in surface waters. However, it was noted that all samples of the collected water exceeded the norm for BOD (Biochemical Oxygen Demand) and COD (Chemical Oxygen Demand), except for the water in the Sluch River, Korzhivka village section..

The article presents the results of the ecological assessment of water resources in Khmelnytskyi region based on sanitary and hygienic indicators. The impact of environmentally hazardous objects on the state of surface waters was determined, and concentrations of pollutants in water ecosystems were identified. As a result of the conducted research, it was found that the surface waters of Khmelnytskyi region, in terms of sanitary and toxicological condition, correspond to an acceptable and moderate level of pollution. The indicator of the limiting criterion of harmfulness ranged from 0.4 to 1.0 units of measurement.